Development of long-acting ARV’s

Development of long-acting ARV’s

Research on improved treatment of HIV infection and pre-exposure prophylaxis (PrEP) continues. Poor adherence to treatment is the critical risk factor for virologic failure and resistance development, and long-acting formulations of anti-HIV medications that need only infrequent dosing may facilitate long-term therapeutic responses. However, such formulations and long-term persistence of drug a...

LONG-ACTING CONTRACEPTIVE AGENTS: TESTOSTERONE ESTERS OF CYCLOALKYLCARBOXYLIC ACIDS

The synthesis of twenty five esters of testosterone (17β -hydroxyandrost- 4-en-3-one) is described. All esters are derivatives of cycloalkycarboxylic acids. Some of the esters possess α- , β -and/or & - substitution in the ester side-chain. The work was undertaken in order to evaluate long-acting male antifertility effect of such esters. Most of the compounds, especially compound No.1, wer...

Long-acting sulfonylureas -- long-acting hypoglycaemia.

long-acting antipsychotics

long-acting (depot) anti-psychotic injection (lai) is an essential component of the treatment of schizophrenia. in this editorial, the journal tries to give a short account of the current ideas and practical aspects of lai, with respect to the iranian experience. two categories of the long-acting injections are discussed mainly regarding their dosage, intervals of their injections and availabil...

Development of clinical pathways for long-acting reversible contraceptives (LARCs).

©FSRH J Fam Plann Reprod Health Care 2008: 34(2) Why was the change needed? Long-acting reversible contraceptives (LARCs) are underused and many health professionals do not feel confident about how best to provide them. In 2003, Gloucestershire Sexual Health Services were successful in bidding for a programme for the National Primary Care Contracting Collaborative. This was to improve the provi...